Journal
EPIDEMIOLOGY AND INFECTION
Volume 139, Issue 12, Pages 1805-1817Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0950268811001531
Keywords
Epidemiology; statistics; vaccine safety
Ask authors/readers for more resources
The self-controlled case-series method was originally developed to investigate potential associations between vaccines and adverse events, and is now commonly used for this purpose. This study reviews applications of the method to vaccine safety investigations in the period 1995-2010. In total, 40 studies were reviewed. The application of the self-controlled case-series method in these studies is critically examined, with particular reference to the definition of observation and risk periods, control of confounders, assumptions and potential biases, methodological and presentation issues, power and sample size, and software. Comparisons with other study designs undertaken in the papers reviewed are also highlighted. Some recommendations are presented, with the emphasis on promoting good practice.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available