Journal
EPIDEMIOLOGY AND INFECTION
Volume 139, Issue 1, Pages 130-138Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0950268810000890
Keywords
Beijing family; IS6110 restriction fragment length polymorphism; mycobacterial interspersed repetitive units; Mycobacterium tuberculosis; spoligotyping
Funding
- China Scholarship Council (CSC)
- Fudan University Graduate School
- National Natural Science Foundation of China [30771843, 30901223]
- China National Key Project for Infectious Disease [2009ZX10003-017]
- Shanghai Leading Academic Discipline Project [B118]
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This study investigated further the association between the Beijing family Mycobacterium tuberculosis circulating in rural China and anti-tuberculosis (TB) drug resistance. In total, 351 M. tuberculosis isolates were collected through a population-based epidemiological study, 223 (63.5%) of which were resistant to at least one anti-TB drug, including 53 (15.1%) multidrug-resistant (MDR) isolates. Spoligotyping found 243 isolates (69.2%) that belonged to the Beijing family. A major subgroup of the Beijing family identified by mycobacterial interspersed repetitive unit (MIRU) genotyping (223325173533), showed significantly higher frequencies of MDR (44.7% vs. 13.7%, OR 6.18, 95% CI 2.68-14.23), katG and rpoB mutations (31.6% vs. 9.3%, OR 4.27, 95% CI 1.86-9.80), and being clustered by IS6110 RFLP genotyping (60.5% vs. 21.0%, OR 6.14, 95% CI 2.82-13.37) in comparison with other Beijing family isolates. Our data suggest that MIRU genotype 223325173533 of the Beijing family is associated with MDR and increased transmissibility.
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