Journal
EPIDEMIOLOGY AND INFECTION
Volume 139, Issue 11, Pages 1710-1719Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0950268810002815
Keywords
GP surveillance systems; infectious disease epidemiology; statistics; vaccines; varicella zoster
Funding
- GlaxoSmithKline
- Sanofi Pasteur MSD
- Munich Center of Health Sciences
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A multivariate time-series regression model was developed in order to describe the 2005-2008 age-specific time-course of varicella sentinel surveillance data following the introduction of a varicella childhood vaccination programme in Germany. This ecological approach allows the assessment of vaccine effectiveness under field conditions by relating vaccine coverage in cohorts of 24-month-old children to the mean number of cases per reporting unit in the sentinel network. For the 1-2 years age group, which is directly affected by the vaccination programme, a one-dose vaccine effectiveness of 83.2% (95% CI 80.2-85.7) was estimated which corresponds to previous approaches assessing varicella vaccine effectiveness in the field in the USA.
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