Journal
EPIDEMIOLOGY AND INFECTION
Volume 138, Issue 3, Pages 347-352Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0950268809990550
Keywords
Cholera; El Tor toxin; epidemic; severe dehydration; Vibrio cholerae
Funding
- National Institute of Health [1R01A139129-01]
- Johns Hopkins Bloomberg School of Public Health
- International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B)
- University of Maryland
- Australian International Development Agency (AusAID)
- Government of Bangladesh
- Canadian International Development Agency (CIDA)
- Government of Japan
- Government of The Netherlands
- Swedish International Development Cooperative Agency (SIDA)
- Swiss Development Cooperation (SDC)
- Department for International Development (DFID), United Kingdom
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During epidemics of cholera in two rural sites (Bakerganj and Mathbaria), a Much higher proportion of patients came for treatment with severe dehydration than was seen in previous years. V. cholerae O1 isolated from these patients was found to be El Tor in its phenotype, but its cholera toxin (CT) was determined to be that of classical biotype. Whether the observed higher proportion of severe dehydration produced by the El Tor biotype was due to a shift from El Tor to classical CT or due to other factors is not clear. However, if cholera due to strains with increased severity spread to other areas where treatment facilities are limited, there are likely to be many more cholera deaths.
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