Journal
EPIDEMIOLOGY AND INFECTION
Volume 137, Issue 8, Pages 1155-1162Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0950268808001945
Keywords
Africa; glycoprotein; Lagos bat virus; lyssavirus; pathogenicity; rabies
Funding
- (Agricultural Research Council, Onderstepoort Veterinary Institute, Rabies Unit, South Africa) [MOKVSA(252/97), LBVSA1982]
- [Agence Francaise de Securite Sanitaire des Aliments (AFSSA), France] [LBV1999AFR]
- National Research Foundation of South Africa
- University of Pretoria International Affairs Officee's Postgraduate Study Abroad Bursary Programme,
- US National Vaccine Program Office
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Lagos bat virus (LBV) constitutes genotype (gt) 2 in the Lyssavirus genus. In contrast to the gt 1 lyssavirus, rabies virus (RABV), LBV was reported to have markedly reduced levels of peripheral pathogenicity. However, this opinion was based on a study of one isolate of LBV only and the reduction in pathogenicity was essentially attributed to the amino-acid substitution at position 333 of glycoprotein ectodomain. In the present study we have demonstrated that peripheral pathogenicity of representatives of LBV in a murine model is as high as that of RABV. Comparison of amino-acid substitutions among the viral glycoproteins, demonstrated significant differences within two antigenic sites between different phylogenetic lineages of LBV. Such molecular variability potentially contributes to differences in peripheral pathogenicity of lyssaviruses.
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