Journal
EPIDEMIOLOGY AND INFECTION
Volume 137, Issue 2, Pages 203-210Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0950268808000782
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Diabetes mellitus (DM) is a known risk factor for pulmonary tuberculosis (PTB). This study aimed to determine if type 2 DM alters manifestations and treatment outcome of PTB. Records of 217 consecutive culture-proven PTB patients were analysed retrospectively. The manifestations and treatment outcomes of 74 patients with type 2 DM (PTB-DM group) were compared to 143 patients without DM (PTB group). PTB-DM patients showed higher frequencies of fever, haemoptysis, positive acid-fast bacilli sputum smears, and consolidation, cavity, and lower lung field lesions on chest radiographs, and higher mortality rate. Furthermore, type 2 DM, age >= 65 years, and extensive radiographic disease were factors independently associated with an unfavorable Outcome. This Study confirmed that clinical manifestations and chest radiographs of PTB patients associated with type 2 DM significantly depart from the typical presentation. Type 2 DM seems to have a negative effect on treatment Outcome of PTB.
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