Journal
EPIDEMIOLOGY AND INFECTION
Volume 137, Issue 1, Pages 73-78Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0950268808000617
Keywords
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Funding
- Japanese Ministry of Education, Culture, Sports, Science and Technology [18580301, 17255009]
- Japanese Ministry of Health, Labour and Welfare [H15-Shinkou-17, H17-Shinkou-ippan-018]
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We determined the genetic relationships and origin of the dengue virus (DENV) responsible for an outbreak of dengue fever (DF) in Guangdong province, China, in 2006. Five DENY type I (DENV-1) isolates were obtained from human serum samples collected from DF patients during the Outbreak. The nucleotide sequences of the E (envelope) gene were compared with those of 48 previous DENV-1 isolates: 18 from Guangdong province, one from Fujian province, one from Zhejiang province, and 28 from other countries in the South Asian region. The results Suggested that Four DENV-1 isolates identified in Guangdong province in 2006 might be in general circulation there, although these DENV-1 viruses may have been originally introduced into the province from other countries. In contrast, one isolate from Guangzhou city in 2006, may have been introduced by a recently imported case from Cambodia.
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