4.6 Article

How Well Quantified Is the Limit of Quantification?

Journal

EPIDEMIOLOGY
Volume 21, Issue -, Pages S10-S16

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/EDE.0b013e3181d60e56

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Funding

  1. American Chemistry Council
  2. Eunice Kennedy Shriver National Institute for Child and Human Development
  3. National Institutes of Health

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Background: Raw data on the relationship between known and measured values of an analyte are collected and analyzed to determine the limit of quantification (LOQ) of an assay. In most LOQ problems, the researcher is given an observed value for the marker of interest if this value is greater than the LOQ, and a missing value (

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