Journal
EPIDEMIOLOGY
Volume 20, Issue 2, Pages 254-264Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/EDE.0b013e31819644cc
Keywords
-
Categories
Funding
- National Heart, Lung, and Blood Institute (NHLBI) [N01-HC-95159-N01-HC-95161, N01-HC-95163-N01-HC-95165, N01-HC-95169, HL72403]
- NIEHS [ES013195, K24ES013195]
- US EPA [R830543, R831697]
- EPA [908987, R831697] Funding Source: Federal RePORTER
Ask authors/readers for more resources
Background: The initiation and acceleration of atherosclerosis is hypothesized as a physiologic mechanism underlying associations between air pollution and cardiovascular effects. Despite toxicologic evidence, epidemiologic data are limited. Methods: In this cross-sectional analysis we investigated exposure to fine particulate matter (PM2.5) and residential proximity to major roads in relation to abdominal aortic calcification, a sensitive indicator of systemic atherosclerosis. Aortic calcification was measured by computed tomography among 1147 persons, in 5 US metropolitan areas, enrolled in the Multi-Ethnic Study of Atherosclerosis. The presence and quantity of aortic calcification were modeled using relative risk regression and linear regression, respectively, with adjustment for potential confounders. Results: We observed a slightly elevated risk of aortic calcification (RR = 1.06; 95% confidence interval = 0.96-1.16) with a 10 mu g/m(3) contrast in PM2.5. The PM2.5-associated risk of aortic calcification was stronger among participants with long-term residence near a PM2.5 monitor (RR = 1.11; 1.00-1.24) and among participants not recently employed outside the home (RR = 1.10; 1.00-1.22). PM2.5 was not associated with an increase in the quantity of aortic calcification (Agatston score) and no roadway proximity effects were noted. There was indication of PM2.5 effect modifidation by lipid-lowering medication use, with greater effects among users, and PM2.5 associations were observed most consistently among Hispanics. Conclusions: Although we did not find persuasive associations across our full study population, associations were stronger among participants with less exposure misclassification. These findings support the hypothesis of a relationship between particulate air pollution and systemic atherosclerosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available