Journal
ENZYME AND MICROBIAL TECHNOLOGY
Volume 53, Issue 4, Pages 288-292Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.enzmictec.2013.03.011
Keywords
Alcohol dehydrogenase; Baeyer-Villiger monooxygenase; Cyclohexanol; Cyclohexanone; epsilon-Caprolactone; Oxidation
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Funding
- German Federal Environmental Foundation (Deutsche Bundesstiftung Umwelt, DBU) [AZ 13234-32, AZ-13268-32]
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The development of a biocatalytic process concept for epsilon-caprolactone, which directly converts cyclohexanol as an easily available industrial raw material into the desired epsilon-caprolactone in a one-pot fashion while only requiring air as sole reagent, is reported. The desired product epsilon-caprolactone was obtained with 94-97% conversion when operating at a substrate concentration in the range of 20-60 mM. At higher substrate concentrations, however, a significant drop of conversion was found. Subsequent detailed studies on the impact of the starting material, intermediate and product components revealed a significant inhibition and partial deactivation of the BVMO by the product epsilon-caprolactone (in particular at higher concentrations) as well as an inhibition of the BVMO by cyclohexanol and cyclohexanone. (C) 2013 Elsevier Inc. All rights reserved.
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