Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 37, Issue 1, Pages 423-430Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2013.12.005
Keywords
Sodium ferulate; Oxymatrine; Ethanol; Anti-inflammatory; Antioxidant
Funding
- Ministry of Science and Technology of the People's Republic of China [2008ZX09101-Z-017]
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The aim of this study was to investigate the effects of the combination of SF and OMT on ethanol-induced liver damage in mice. The animal liver wet/dry weight (W/D) ratio and liver tissue histopathology, alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), malondialdehyde (MDA), superoxidase dismutase (SOD), C-reactive protein (CRP), interleukin-6 (IL-6), and nuclear factor kappa B (NF-kappa B) levels were measured. The data indicated that the levels of ALT, AST, TG, CRP, IL-6, NF-kappa B and MDA significantly decreased and that SOD activity improved after treatment with the combination of SF and OMT; the same effects were not observed with the same dose of SF or OMT when used alone. These results indicated that the combination of SF and OMT had a protective effect on ethanol-induced liver damage in mice and that antioxidation and anti-inflammatory effects might be involved in this protective mechanism. (C) 2013 Elsevier B.V. All rights reserved.
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