Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 38, Issue 2, Pages 643-652Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2014.07.011
Keywords
Hypertension; Vanillic acid; L-NAME; Cardiac marker enzymes; eNOS expression; Left ventricular function
Funding
- Annamalai University for the financial assistance in the form of University Research Fellowship
- Welcome Trust Research Laboratory, Department of Gastrointestinal Sciences, Christian Medical College and Hospital, Vellore 632 004, India,
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The objective of the present study is to investigate the effects of vanillic acid on blood pressure, cardiac marker enzymes, left ventricular function and endothelial nitric oxide synthase (eNOS) expression in N-omega-nitro-L-arginine methyl ester hydrochloride (L-NAME) induced hypertension in male albino Wistar rats. In hypertensive rats, mean arterial pressure (MAP), heart rate, cardiac marker enzymes and organ weight were increased. Impaired left ventricular function and decreased aortic eNOS expression was also observed in hypertensive rats. Moreover, treatment with vanillic acid exhibited beneficial effect on blood pressure, left ventricular function and cardiac marker enzymes. In addition, treatment with vanillic acid on hypertensive rats had upregulated eNOS expression and showed beneficial effects evidenced by histopathology and ultrastructural observations of aorta. In conclusion, vanillic acid has enough potential to normalize hypertension and left ventricular function in L-NAME induced hypertensive rats. With additional studies, vanillic acid might be used as a functional drug or as an adjuvant in the management of hypertension. (C) 2014 Elsevier B.V. All rights reserved.
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