Comparison of embryo toxicity using two classes of aquatic vertebrates

Toxicity tests of musk ketone (MK) and tetrabromobisphenol-A (TBBPA) on embryos were conducted in two amphibian species, Xenopus (Silurana) tropicalis and the Swedish native species Rana arualis. TBBPA was also tested on fish embryos of Danio rerio. All species were tested in similar experimental setup. Musk ketone caused decreased heart rates at concentrations from 10 and 100 mu g/L in R. arualis and X. tropicalis, respectively. TBBPA caused effects at 1000 mu g/L in all three species. The responses were comparable between all three species which supports the relevance for using data from non-native species in national risk assessment. (C) 2013 Elsevier B.V. All rights reserved.