Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 38, Issue 2, Pages 607-615Publisher
ELSEVIER
DOI: 10.1016/j.etap.2014.08.001
Keywords
High glucose; Octaphlorethol A; Oxidative stress; Zebrafish model; Hyperglycemia
Funding
- Basic Science Research Program through the National Research Foundation [2012R1A1A2005479]
- Korea (NRF)
- Ministry of Education, Science and Technology [2012R1A1A2005479]
- National Research Foundation of Korea [2012R1A1A2005479] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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We investigated the protective effect of octaphlorethol A (OPA) isolated from Ishige foliacea against high-glucose-induced oxidative damage, as indicated by reactive oxygen species (ROS) generation, lipid peroxidation, and cell death, in human umbilical vein endothelial cells (HUVECs) and in a zebrafish model. OPA treatment significantly and dose-dependently decreased ROS generation, lipid peroxidation, and cell death in HUVECs and in a zebrafish model. Our results show that OPA can protect HUVECs and zebrafish against high glucose by suppressing intracellular ROS generation, lipid peroxidation, and cell death. (C) 2014 Elsevier B.V. All rights reserved.
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