Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 36, Issue 1, Pages 88-96Publisher
ELSEVIER
DOI: 10.1016/j.etap.2013.03.014
Keywords
Phthalates; Reproductive; Carcinogenesis; Asthma; Autism; Toxicity
Funding
- Rete Regionale di informazione sul farmaco: informazione, formazione, e farmacovigilanza
- Regione Calabria on Behalf of Agenzia Italiana del Farmaco (AIFA)
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Phthalates are chemicals widely used in industry and the consequences for human health caused by exposure to these agents are of significant current interest. Phthalate toxicity targets the reproductive and respiratory systems primarily, but they also may be involved in the processes of carcinogenesis and even in autism spectrum disorders. This article discusses the molecular and cellular mechanisms involved in organ toxicity of phthalates; furthermore, pharmacokinetic, chemistry and the European regulation are summarized. (C) 2013 Elsevier B.V. All rights reserved.
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