Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 36, Issue 3, Pages 1015-1021Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2013.09.003
Keywords
Arsenite; Arsenate; Arsenic trioxide; Dimethylarsinic acid; Oxidative stress; Selenoenzymes
Funding
- Ministry of Education of the Czech Republic [0021620819]
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In this study, oxidative stress-related parameters and As retention were examined in liver and kidneys of male Wistar rats exposed to arsenic trioxide, sodium arsenite (iAsIII), sodium arsenate (iAsV), and dimethylarsinic acid (DMAsV) at a single ip dose of 3.8 mgAs/kgbw, at 24h post-exposure. In liver, lipid peroxidation increased in iAsIII-exposed rats, glutathione peroxidase activity decreased in inorganic arsenic (iAs)-exposed rats, and catalase and thioredoxin reductase activities decreased significantly in all As-exposed groups. Both As (III) and As(V) exposure elevated GSH level with no effect on glutathione reductase activity. In kidneys, catalase activity decreased significantly in iAs-exposed, rats; GSH level, glutathione reductase and thioredoxin reductase activity decreased in DMAsV-treated, rats. The tissue As retention was higher in kidneys compared to liver and was also higher in As(III)-exposed compared to As(V)-exposed rats. The results demonstrate similar potency Of inorganic As(III) and As(V) compounds to inhibit/induce antioxidant defense system, with liver being more vulnerable to acute As(III)- and As(V)-induced oxidative stress. (C) 2013 Elsevier B.V. All rights reserved.
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