4.6 Review

Recent progress in studies of metallic nickel and nickel-based nanoparticles' genotoxicity and carcinogenicity

Journal

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 34, Issue 3, Pages 644-650

Publisher

ELSEVIER
DOI: 10.1016/j.etap.2012.08.012

Keywords

Genotoxicity; Carcinogenicity; Nickel; Nanoparticles

Funding

  1. National Nature Science Foundation of China [81273111]
  2. Foundations of Innovative Research Team of The Educational Commission of Zhejiang Province [T200907]
  3. Nature Science Foundation of Ningbo City [2012A610185]
  4. Ningbo Scientific Project [SZX11073]
  5. Scientific Innovation Team of Ningbo [2009B21002]
  6. K.C. Wong Magna Fund in Ningbo University

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Recently, nanoparticles have been the focus of many research and innovation. Metallic nickel and nickel-based nanoparticles are among those being exploited. Nickel fine particles are known to be genotoxic and carcinogenic. It has been discovered that many properties of nano sized elements and materials are not present in their bulk states. The nano size of these particles renders them the ability to be easily transported into biological systems, thus raising the question of their effects on the susceptible system. Therefore scientific research on the effects of nickel nanoparticles is important. This mini-review intends to summarize the current knowledge on the genotoxicity and carcinogenicity potential of metallic nickel and nickel-based nanoparticles implicated in in vitro and in vivo mammalian studies. (C) 2012 Elsevier B.V. All rights reserved.

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