Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 34, Issue 3, Pages 941-948Publisher
ELSEVIER
DOI: 10.1016/j.etap.2012.08.001
Keywords
C-Phycocyanin; Ornithine decarboxylase; Transglutaminase2; Cyclooxygenase-2; Interlukin-6; pSTAT3
Funding
- Indian Council of Medical Research, New Delhi
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C-Phycocyanin (C-PC), a biliprotein from the sea weed, has been shown to have the beneficial effects like antioxidant, anti-inflammatory, neuroprotective, and hepatoprotective properties and is used as food supplement. We are showing the effect of C-Phycocyanin on the early events altered by tumor promoter. TPA induced the expression of critical events of tumorigenesis like ornithine decarboxylase, cyclooxygenase-2, interlukin-6 and pSTAT3 in mouse skin after 5 h of application, whereas expression of transglutaminase2 was decreased at this time point. This TPA-caused altered expression of genes was prevented in presence of C-Phycocyanin. This prevention by C-Phycocyanin appeared to be dependent on the dose of C-Phycocyanin used. The results are useful for the detailed study on the preventive effect of C-Phycocyanin on TPA induced tumor promotion. (C) 2012 Elsevier B.V. All rights reserved.
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