Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 33, Issue 1, Pages 16-25Publisher
ELSEVIER
DOI: 10.1016/j.etap.2011.10.003
Keywords
Cd; Antioxidants; LPO; Accumulation; Japanese flounder
Funding
- National Natural Science Foundation of PR China [40821004, 31061160187]
- Ministry of Science and Technology of PR China [2009AA09Z401]
- State Oceanic Administration of PR China [200905019]
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This study investigated the accumulation of cadmium (0-8 mg Cd L-1) and its toxicological effects on oxidative stress biomarkers in different tissues of Japanese flounder juveniles. Following Cd exposure for 28 d, accumulation of Cd in fish was dose-dependent and tissue-specific, with the greatest accumulation in the liver, followed by the kidney, gill, and muscle. Although the gill and liver mounted active antioxidant responses at >= 4 mg L-1 Cd including a decrease in glutathione level and GST and GPx activities, the antioxidant response failed to prevent lipid peroxidation induction in these organs. In the kidney, increased GPx and GST activities and decreased SOD activity were observed in fish exposed to high Cd concentrations, but LPO levels did not significantly differ among the exposure concentrations. The gill was most sensitive to oxidative damage, followed by the liver; the kidney was the least affected tissue. (C) 2011 Published by Elsevier B.V.
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