Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 34, Issue 2, Pages 228-234Publisher
ELSEVIER
DOI: 10.1016/j.etap.2012.04.005
Keywords
Lignophenols; Obesity; Sterol regulatory element-binding protein-1c; Acetyl-CoA carboxylase; High-fat diet
Funding
- Japan Science and Technology Agency [AS221Z02004G]
- Grants-in-Aid for Scientific Research [24700836, 23500960] Funding Source: KAKEN
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The effect of lignin-derived lignophenols on lipid metabolism in the livers of rats fed a high-fat diet was investigated. Rats fed a diet providing 45% of energy from fat were divided into 2 groups, namely 0% and 0.5% lignophenols-containing diets. The controls were fed a diet providing 10% of energy from fat. Plasma blood parameters, protein expression of acetyl-CoA carboxylase (ACC) and sterol regulatory element-binding protein (SREBP)-1, and SREBP-1c mRNA expression in the livers were examined. The plasma triglyceride levels in the rats fed lignophenols-containing diets were decreased. SREBP-1c mRNA expression in the rats fed lignophenols-containing diets was significantly reduced compared with the rats fed high-fat diets, and phosphorylated ACC protein in the rats fed lignophenols-containing diets was significantly increased. Our results suggested that lignophenols suppress the expression of SREBP-1c mRNA and the phosphorylation of ACC in the liver, and may lead to a decrease in plasma triglyceride levels. (C) 2012 Elsevier B.V. All rights reserved.
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