Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 31, Issue 1, Pages 88-99Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2010.09.009
Keywords
Bisphenol A; 17 beta-estradiol; Exploration; Anxiety; Social behaviors
Funding
- National Natural Science Foundation of China [30670273, 30970370]
- Fundamental Research Fund for the Central Universities [GK200901011]
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Bisphenol A (BPA) is a widespread endocrine disrupting chemical that influences adult physiology and behavior after perinatal exposure. However, it is not clear if pubertal exposure to BPA exerts hormone dependent effects on behaviors. Using C57BL/6J mice, we sought to determine how pubertal exposure to BPA affects locomotion, exploration, anxiety and sociability in adulthood. Compared to controls, pubertal exposure to BPA or E-2 (17 beta-estradiol) significantly altered female exploratory and anxiety behavior. Moreover, BPA and E-2-treated female mice displayed increased levels of affiliation to female stimulus mice and decreased levels of affiliation to male stimulus mice; while our control males showed affiliation preference to female stimulus. These results indicate that pubertal exposure to BPA or E-2 may masculinize female social and emotional behavior. (C) 2010 Elsevier B.V. All rights reserved.
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