Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 32, Issue 3, Pages 465-471Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2011.08.013
Keywords
Sodium ferulate; IUGR; Placenta; Oxidative stress; Antioxidative functions; P-glycoprotein (P-gp)
Funding
- National Natural Science Foundation of China [30830112, 81072709, 30672566, 30901213]
- Specialized Research Fund for the Doctoral Program of Higher Education [200804861030]
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This study was aimed to explore the therapeutic effect of sodium ferulate (SF) on rats with intrauterine growth retardation (IUGR), and then to clarify the corresponding mechanism. Pregnant rats were divided into normal group, tobacco/alcohol exposure group, and tobacco/alcohol + SF groups. Fetal developmental indices, placental weight, histological alteration, oxidative and antioxidative-function (e.g. MDA, SOD, CAT) and Mdr1 levels were assayed. Results showed exposure to tobacco/alcohol resulted in reduced fetal developmental indices and placental histological alteration, as well as the increased MDA content, decreased SOD and CAT activities and decreased Mdr1a level. After SF treatment, fetal developmental indices, and placental weight, histological alteration, oxidative and antioxidative-function and mdr1a levels were reversed. Our study indicated SF may be effective in reversing IUGR production, and its underlying mechanism may be due to enhanced placental antioxidative function and P-gp expression, which may be related to IUGR formation by tobacco/alcohol exposure. (C) 2011 Elsevier B.V. All rights reserved.
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