Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 31, Issue 3, Pages 453-459Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2011.02.008
Keywords
Tobacco; Candle smoke; Incense smoke; Endothelial dysfunction; Flow-mediated dilation; Blood gases; Carbon monoxide
Funding
- Saskatchewan Health Research Foundation
- Western College of Veterinary Medicine
- Natural Sciences & Engineering Research Council of Canada
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The aim of this study was to determine if carbon monoxide (CO) is responsible for acute adverse cardiovascular effects of different sources of smoke: second-hand tobacco smoke (SHS), incense and candle smoke. Endothelial function was tested using flow-mediated dilation (FMD) in pigs and was shown to be sensitive to nitric oxide synthase blockade. Subsequent experiments showed that FMD was significantly impaired compared to sham-exposed pigs at 30 min after a 30-min exposure to all three sources of smoke. In contrast, SHS significantly increased systolic, diastolic and pulse pressures compared to sham-exposure, while both incense and candle smoke exposure had no effect. The FMD impairment correlated well with CO levels in the exposure chamber, but not total particulates or venous CO-hemoglobin. Therefore, this study suggests a gas phase component of smoke that accompanies CO, but not CO itself, is responsible for acute endothelial dysfunction after SHS, incense or candle smoke exposure. (C) 2011 Elsevier B.V. All rights reserved.
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