Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 29, Issue 2, Pages 173-182Publisher
ELSEVIER
DOI: 10.1016/j.etap.2009.12.007
Keywords
Fine particles; HEp-2 cells; Persistent free radical; Oxidative stress; Resveratrol
Funding
- National Institute of Environmental Health Science Center(NIEHS) [R01 ES015050-01, R01 ES015450]
Ask authors/readers for more resources
Strong correlations exist between exposure to PM2.5 and adverse pulmonary effects. PM2.5 Consists Of fine (<= 2.5 mu m) and Ultrafine (<= 0.1 mu m) particles with ultrafine particles accounting for >70% of the total particles. Environmentally persistent free radicals (EPFRs) have recently been identified in airborne PM2.5 To determine the adverse pulmonary effects of EPFRs associated with exposure to elevated levels of PM2.5, we engineered 2.5 mu m Surrogate EPFR-particle systems. We demonstrated that EPFRs generated greater oxidative stress in vitro,which was partly responsible for the enhanced cytotoxicity following exposure. in vivo studies using rats exposed to EPFRs containing particles demonstrated minimal adverse pulmonary effects. Additional studies revealed that fine particles failed to reach the alveolar region. Overall, our study implies qualitative differences between the health effects of PM size fractions. (C) 2010 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available