Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 30, Issue 1, Pages 37-44Publisher
ELSEVIER
DOI: 10.1016/j.etap.2010.03.016
Keywords
Genistein; Osteolytic bone metastasis; Osteoclast; Bone mass; Bone microstructure
Funding
- Science and Technology Commission of Shanghai Municipality [064119512]
- Shanghai Municipal Health Bureau [2009003]
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In this study, the effective activity of genistein on osteolytic bone metastasis and bone mineral was investigated. Female BALB/c-nu/nu mice were injected with estrogen receptor-negative human breast cancer cells, MDA-MB-231, into left cardiac ventricle to form osteolytic bone metastases, and administered genistein subcutaneously after rachologically small but defined osteolytic metastases had been observed (protocol 1), simultaneously with cancer cells inoculation (protocol 2) and prophylactically 7 days before inoculation of cancer cells (protocol 3). In all protocols, genistein (10 mg/kg/day) markedly reduced the number and volume of osteolytic bone metastases assessed by radiography and the number of osteoclasts. Furthermore, histomorphometrical analysis revealed that genistein markedly increased trabecular area (Tb.Ar%), trabecular thickness (Tb.Th) and trabecular number (Tb.N), and decreased trabecular separation (Tb.Sp). These results thus demonstrate that genistein could inhibit osteolytic bone metastases, suppress bone resorption, increase bone mass and improve bone microstructure in bone metastases of breast cancer. (C) 2010 Elsevier B.V. All rights reserved.
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