Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 26, Issue 3, Pages 362-365Publisher
ELSEVIER
DOI: 10.1016/j.etap.2008.05.004
Keywords
Crassostrea gigas; Oyster; Sewage; Biomarker; Biotransformation
Funding
- Brazilian Council for the Scientific and Technological Development (CNPQ) [475995/2003-1]
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Pacific oysters, Crassostrea gigas, were exposed to untreated sewage diluted in seawater. After 48 h of exposure, the expression of genes associated to biotransformation pathways (CYP356A1. GSTO, MDR, FABP and ALAS) were analyzed in gills through semi-quantitative RT-PCR. A significant induction in all genes analyzed in the sewage-exposed oysters was observed. These genes are related to phase I (CYP356A1), phase II (GSTO) and phase III (MDR) biotransformation systems, to the uptake and transport of hydrophobic ligands (FABP) and to the synthesis of prosthetic group heme (ALAS). The organisms were able to survive in contaminated conditions since protective mechanisms have been properly stimulated. (C) 2008 Elsevier B.V. All rights reserved.
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