Journal
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
Volume 32, Issue 8, Pages 1793-1799Publisher
WILEY
DOI: 10.1002/etc.2245
Keywords
Environmental estrogen; Bisphenol A; Nonylphenol; Oxidative stress; Immune system
Categories
Funding
- National Natural Science Foundation of China [31100376, 41073073, 21007039]
Ask authors/readers for more resources
Bisphenol A (BPA) and nonylphenol (NP) are well known endocrine-disrupting chemicals (EDCs) ubiquitous in the aquatic environment and are an ecotoxicological risk for the health of aquatic organisms. Limited attention has been given to the immunotoxicity of these chemicals. The present study revealed a concentration-dependent increase of reactive oxygen species content and an induced expression of redox-sensitive transcription factors in zebrafish embryos after exposure to various concentrations of BPA, NP, and BPA/NP mixture for 4h to 168h postfertilization. Transcription of genes related to the immune response, including IFN, IL1, IL10, Mx, TNF, CC-chemokine, and CXCL-clc, were significantly up-regulated on exposure to EDCs. A significant induction of concentrations of proinflammatory mediator, nitric oxide, accompanied by an increase in the activity of nitric oxide synthase (NOS) and an upregulation of inducible NOS gene expression, was detected in zebrafish embryos on exposures to EDCs. To elucidate the potential mechanisms by which BPA and NP activate the innate immune response, expression profiles of genes related to the Toll-like receptors (TLRs) signaling pathway were examined. Expressions of TLR3, TRIF, MyD88, SARM, IRAK4, and TRAF6 were altered on exposure to EDCs. The authors' results demonstrate that exposure to BPA and NP significantly affects the expression of genes related to immune response in zebrafish embryos following oxidative stress. Environ Toxicol Chem 2013;32:1793-1799. (c) 2013 SETAC
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available