Journal
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
Volume 31, Issue 6, Pages 1396-1406Publisher
WILEY
DOI: 10.1002/etc.1825
Keywords
17 ss-Estradiol; Estrone; Estriol; 17a-Ethinylestradiol; Predicted-no-effect concentration
Categories
Funding
- PhRMA
Ask authors/readers for more resources
The authors derive predicted-no-effect concentrations (PNECs) for the steroid estrogens (estrone [E1], 17 beta-estradiol [E2], estriol [E3], and 17a-ethinylestradiol [EE2]) appropriate for use in risk assessment of aquatic organisms. In a previous study, they developed a PNEC of 0.35?ng/L for EE2 from a species sensitivity distribution (SSD) based on all available chronic aquatic toxicity data. The present study updates that PNEC using recently published data to derive a PNEC of 0.1?ng/L for EE2. For E2, fish were the most sensitive taxa, and chronic reproductive effects were the most sensitive endpoint. Using the SSD methodology, we derived a PNEC of 2?ng/L for E2. Insufficient data were available to construct an SSD for E1 or E3. Therefore, the authors used in vivo vitellogenin (VTG) induction studies to determine the relative potency of the steroid estrogens to induce VTG. Based on the relative differences between in vivo VTG induction, they derive PNECs of 6 and 60?ng/L for E1 and E3, respectively. Thus, for long-term exposures to steroid estrogens in surface water (i.e., >60 d), the PNECs are 6, 2, 60, and 0.1?ng/L for E1, E2, E3, and EE2, respectively. Higher PNECs are recommended for short-term (i.e., a few days or weeks) exposures. Environ. Toxicol. Chem. 2012;31:13961406. (c) 2012 SETAC
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available