Journal
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
Volume 31, Issue 9, Pages 2117-2123Publisher
WILEY
DOI: 10.1002/etc.1918
Keywords
CdSe; Quantum dots; Copper; Zebrafish; Facilitated transport; Toxicological effect
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Funding
- National Natural Science Foundation of China [40901148, 40871223]
- Major State Basic Research Development Program of China [2011CB200904]
- National Environmental Protection Public Welfare Science and Technology Research Program of China [200909089]
- National Forestry Public Welfare Science and Technology Research Program of China [201104088]
- Fundamental Research Funds for the Central Universities [WB0911011]
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Quantum dots (QDs) have strong adsorption capacity; therefore, their potential toxicity to aquatic organisms from the facilitated transport of other trace toxic pollutants when they coexist has received increasing interest. However, the impact of cadmium selenium (CdSe) QDs and copper ion (Cu2+) joint exposure on zebrafish (Danio rerio) embryo and larvae remains almost unknown. Therefore, the present study was performed to determine the developmental toxicities to zebrafish exposed to combined pollution with CdSe QDs (500?mu g/L) and Cu2+ (0, 0.1, 1, 10, and 100?mu g/L CuC12) compared with single exposure. Our findings for the first time revealed that: (1) QDs facilitated the accumulation of Cu2+ in zebrafish; (2) QDs caused higher mortality, lower hatch rate, and more malformations of the exposed zebrafish; (3) junction, bifurcation, crossing, particles, and aggregation of the exposed FLI-1 transgenic zebrafish larvae can be observed; (4) embryo cell apoptosis appeared in the head and tail region; and (5) synergistic effects played an important role during joint exposure. These observations provide a basic understanding of CdSe QDs and Cu2+ joint toxicity to aquatic organisms and suggest the need for additional research to identify the toxicological mechanism. Environ. Toxicol. Chem. 2012; 31: 21172123. (c) 2012 SETAC
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