Journal
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
Volume 30, Issue 3, Pages 582-587Publisher
WILEY
DOI: 10.1002/etc.432
Keywords
Clotrimazole; Dissipation; Biosolids; Endocrine disruption; Antifungal
Categories
Funding
- Health Canada
- Ontario Ministry of the Environment through the Canada-Ontario
- National Sciences and Engineering Research Council of Canada
Ask authors/readers for more resources
Clotrimazole is a broad-spectrum antimycotic drug used for the treatment of dermatological and gynecological infections; it is incompletely broken down during sewage treatment and could potentially reach agricultural land through the application of municipal biosolids or wastewater. In the absence of any environmental fate data, we evaluated the persistence and dissipation pathways of H-3-clotrimazole during laboratory incubations of agricultural soils. Clotrimazole was removed from a loam (time to dissipate 50% = 68 d), a sandy loam (time to dissipate 50% = 36 d), and a clay loam (time to dissipate 50% = 55 d), with formation of nonextractable residues being the major sink for H-3. Their parent compound had no significant mineralization, as evidenced by the lack of formation of (H2O)-H-3. Up to 15% of the applied radioactivity was recovered in the form of [H-3]-(2-chlorophenyl)diphenyl methanol. The rate of clotrimazole dissipation in the loam soil did not vary with moisture content, but it was slower at a lower temperature (number of days to dissipate 50% = 275.6 d at 4 degrees C). Addition of municipal biosolids to the loam soil did not vary the clotrimazole dissipation rate. In summary, the present study has established that clotrimazole is dissipated in soil, at rates that varied with soil texture and temperature. Clotrimazole dissipation was accompanied by the formation of nonextractable residues and detectable extractable residues of the transformation product (2-chlorophenyl)diphenyl methanol. Environ. Toxicol. Chem. 2011;30:582-587. (C) 2010 SETAC
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available