Journal
ENVIRONMENTAL TOXICOLOGY
Volume 31, Issue 5, Pages 533-542Publisher
WILEY
DOI: 10.1002/tox.22065
Keywords
genotoxicity; gills; histopathology; lipid peroxidation; liver; plasma ions; Na+; K+-ATPase; H+-ATPase; carbonic anhydrase
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Funding
- National Science and Technology Institute (INCT) [573949/2008-5]
- Brazilian Council for Scientific and Technological Development (CNPq) [132972/2011-5, 374081/2012-3]
- Coordination of the Improvement of Higher Level Personnel (CAPES) [2276/2011]
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The action of diflubenzuron (DFB) was evaluated in a freshwater fish, Prochilodus lineatus, after exposure to 0.06, 0.12, 0.25, or 0.50 mg L-1 DFB for 14 days. Erythrocyte nuclear abnormalities (ENA), the gill activity of Na+/K+-ATPase, H+-ATPase and carbonic anhydrase (CA), and lipid peroxidation (LPO) and histopathological changes in the gills and liver were determined. The number of micronuclei increased in fish exposed to 0.25 and 0.50 mg L-1 DFB. Plasma Cl- and the CA activity decreased, while the activity of Na+/K+-ATPase and of H+-ATPase increased in fish exposed to 0.25 and 0.50 mg L-1 DFB. LPO did not change in the gills but increased in the liver of fish exposed to 0.25 and 0.50 mg L-1 DFB. In the gills, histopathological changes indicated disperse lesions and slight to moderate damage in fish exposed to 0.50 mg L-1 DFB, whereas in the liver, these changes were significantly greater in fish exposed to 0.25 and 0.50 mg L-1 DFB, indicating moderate to severe damage. Continuous exposure to DFB is potentially toxic to P. lineatus, causing heath disorders when the fish is exposed to the two highest DFB concentrations, which are applied to control parasites in aquaculture and to control mosquito populations in the environment. (c) 2014 Wiley Periodicals, Inc. Environ Toxicol 31: 533-542, 2016.
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