Journal
ENVIRONMENTAL TOXICOLOGY
Volume 31, Issue 6, Pages 655-662Publisher
WILEY
DOI: 10.1002/tox.22077
Keywords
titanium dioxide nanoparticles; mice; hippocampus; glutamate-glutamine cyclic pathway; glutamate receptors
Categories
Funding
- National Natural Science Foundation of China [81273036, 81473007, 30901218]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- National Bringing New Ideas Foundation of Student of Soochow University [201310285040Z, 201410285040Z]
Ask authors/readers for more resources
Titanium dioxide nanoparticles (TiO2 NPs) have been used in environmental management, food, medicine, and industry. But TiO2 NPs have been demonstrated to cross the blood-brain barrier and store up in the brain organization, leading to glutamate-mediated neurotoxicity. However, the neurotoxicity in the brain is not well understood. In this study, mice were exposed to 1.25, 2.5, or 5 mg/ kg body weight TiO2 NPs for 9 months, and the glutamate-glutamine cyclic pathway and expressions of glutamate receptors associated with the hippocampal neurotoxicity were investigated. Our findings showed elevations of glutamate release and phosphate-activated glutaminase activity, and reductions in glutamine and glutamine synthetase in the hippocampus following exposure to TiO2 NPs. Furthermore, TiO2 NPs significantly inhibited the expression of N-methyl-D-aspartate receptor subunits (including NR1, NR2A, and NR2B) and metabotropic glutamate receptor 2 in mouse hippocampus. These findings suggest that the imbalance of glutamate metabolism triggered inhibitions of glutamate receptor expression in the TiO2 NP-exposed hippocampus. (C) 2014 Wiley Periodicals, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available