Journal
ENVIRONMENTAL TOXICOLOGY
Volume 24, Issue 3, Pages 211-217Publisher
WILEY
DOI: 10.1002/tox.20418
Keywords
nano copper oxide (CuO); voltage-dependent potassium currents; hippocampus; biological effects; pyramidal neurons
Categories
Funding
- NBRPC [2007CB914803]
- Municipal Science Foundation Research of Tianjin [06YFJMJC09400]
- EPSRC [EP/D07942X/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/D07942X/1] Funding Source: researchfish
Ask authors/readers for more resources
The effects of nano particles of CuO on voltage-dependent potassium currents were studied in acutely isolated CA1 pyramidal neurons of rat hippocampus using the whole-cell patch-clamp techniques. Nano particles of CuO had small effects on transient outward potassium current (I-A, no statistical significance) and mainly inhibited delayed rectifier potassium current (I-K) in the concentration of 5 x 10(5) g/mL. Nano particles of CuO didn't shift the steady-state activation curve of I-K and I-A but negatively shifted the inactivation curve of I-K. The effects on inactivation curve of I-A had no statistical significance. These results suggested that blockades of K+ currents by nano particles of CuO could be preferential for I-k for the first time. This may interfere with the normal function of nerve cells. (C) 2008 Wiley Periodicals. Inc. Environ Toxicol 24:211-217. 2009.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available