Journal
JOURNAL OF RHEUMATOLOGY
Volume 42, Issue 7, Pages 1209-1212Publisher
J RHEUMATOL PUBL CO
DOI: 10.3899/jrheum.141513
Keywords
CARDIAC DISEASE; GRANULOMATOSIS WITH POLYANGIITIS; VASCULITIS
Categories
Funding
- NCATS NIH HHS [UL1 TR000439] Funding Source: Medline
- NCRR NIH HHS [U54 RR019497] Funding Source: Medline
- NIAMS NIH HHS [U54 AR057319, U01 AR51874 04, U54AR057319, U01 AR051874] Funding Source: Medline
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Objective. To determine frequency and outcomes of granulomatosis with polyangiitis (GPA)-related cardiac disease in a North American GPA cohort. Methods. Analysis was done of all patients in the Vasculitis Clinical Research Consortium Longitudinal Study of GPA. Demographic and clinical characteristics of patients with and without GPA-related cardiac involvement were compared. Results. Of 517 patients with GPA, 3.3% had cardiac involvement. No differences were observed between patients with or without cardiac involvement in terms of demographics, antineutrophil cytoplasmic antibody positivity, or relapse rate. Conclusion. Cardiac involvement in GPA is rare and heterogeneous. In this cohort, cardiac involvement was not associated with a higher rate of relapse or premature death.
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