Journal
ENVIRONMENTAL SCIENCE & TECHNOLOGY
Volume 48, Issue 12, Pages 7026-7033Publisher
AMER CHEMICAL SOC
DOI: 10.1021/es501306t
Keywords
-
Categories
Funding
- Memorial Grant Fund of Anna Claessen la Cour for Graduate Studies and Research in Denmark
- A. P. Mollers Fund for Icelandic Students in Denmark
Ask authors/readers for more resources
Dynamic models for toxic effects [toxicokinetic-toxicodynamic (TKTD) models] are increasingly used in the analysis of toxicity data for single-chemical exposure. However, these models also offer a natural extension to the effects of chemical mixtures. Here, we demonstrate how a simple model for the energy budget (DEBkiss) can be used to interpret the effects of cadmium and fluoranthene, in both single and mixed exposure, on the nematode Caenorhabditis elegans. The data for all time points and all end points (growth and reproduction) are combined into a single coherent framework. These modeling results are compared to a more traditional independent-action approach based on the dose response curves for a single end point at a single time point. The analysis with DEBkiss does not lead to a radically different interpretation of the mixture effects, both indicating an antagonistic interaction in the mixture. The DEBkiss analysis does, however, provide much more insight into the relevant dynamic processes underlying the toxic effect on the organism and allows for the generation of mechanistic hypotheses that can be used to guide further research.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available