Journal
JOURNAL OF RENAL NUTRITION
Volume 25, Issue 5, Pages 399-403Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.jrn.2015.01.017
Keywords
-
Categories
Funding
- Princess Alexandra Private Practice Trust Fund postgraduate scholarship
- Queensland Government, Health and Medical Research Health Research Fellowship
- Lions Senior Medical Research Fellowship
Ask authors/readers for more resources
There is increasing clinical evidence that patients with chronic kidney disease (CKD) have a distinctly dysbiotic intestinal bacterial community, termed the gut microbiota, which in turn drives a cascade of metabolic abnormalities, including uremic toxin production, inflammation, and immunosuppression, that ultimately promotes progressive kidney failure and cardiovascular disease. As the gut microbiota is intimately influenced by diet, the discovery of the kidney-gut axis has created new therapeutic opportunities for nutritional intervention. This review discusses the metabolic pathways linking dysbiotic gut microbiota with adverse health outcomes in patients with CKD, as well as novel therapeutic strategies for targeting these pathways involving dietary protein, fiber, prebiotics, probiotics, and synbiotics. These emerging nutritional interventions may ultimately lead to a paradigm shift in the conventional focus of dietary management in CKD. (C) 2015 by the National Kidney Foundation, Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available