Journal
ENVIRONMENTAL SCIENCE & TECHNOLOGY
Volume 45, Issue 14, Pages 6018-6024Publisher
AMER CHEMICAL SOC
DOI: 10.1021/es200790x
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [41073067]
- NSF [CMMI-0531171]
- BARD [IS-4353-10]
- USDA [MAS 00978]
Ask authors/readers for more resources
Adsorption of phenanthrene on carbon nanotubes (CNTs) and bioaccessibility of adsorbed phenanthrene were studied in simulated gastrointestinal fluids. Adsorption of phenanthrene on CNTs was suppressed in pepsin (800 mg/L) solution (gastric) and bile salt (500 and 5000 mg/L) fluids (intestinal). In addition to competitive sorption, pepsin and high-concentration bile salt (5000 mg/L, above critical micelle concentration) solubilized phenanthrene (3 and 30 times of the water solubility, respectively), thus substantially reduced phenanthrene adsorption on CNTs. Pepsin and bile salts also increased the rapidly desorbing phenanthrene fraction from CNTs. The rapidly desorbing phase lasted less than 1 h for all CNTs. Further, 43-69% of phenanthrene was released from CNTs after desorption in the simulated gastric and intestinal fluid at low bile salt concentration while 53-86% was released in the gastric and intestinal fluid at high bile salt concentration. These findings suggest that the release of residual hydrophobic organic compounds from CNTs could be enhanced by biomolecules such as pepsin and bile salts in the digestive tract, thus increasing the bioaccessibility of adsorbed phenanthrene and possibly the overall toxicity of phenanthrene associated CNTs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available