Journal
ENVIRONMENTAL RESEARCH
Volume 116, Issue -, Pages 26-35Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.envres.2012.04.010
Keywords
Cortisol; Thyroid hormone; Contaminants; Organohalogens; Polar bear; HPA axis
Funding
- Prince Albert II of Monaco Foundation
- Danish Cooperation for Environment in the Arctic
- Commission for Scientific Research in Greenland, Norwegian Research Council
- Norwegian University of Science and Technology (NTNU)
- US NIH [RR11122, RR00168]
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The multivariate relationship between hair cortisol, whole blood thyroid hormones, and the complex mixtures of organohalogen contaminant (OHC) levels measured in subcutaneous adipose of 23 East Greenland polar bears (eight males and 15 females, all sampled between the years 1999 and 2001) was analyzed using projection to latent structure (PLS) regression modeling. In the resulting PLS model, most important variables with a negative influence on cortisol levels were particularly BDE-99, but also CB-180, -201, BDE-153, and CB-170/190. The most important variables with a positive influence on cortisol were CB-66/95, alpha-HCH, TT3, as well as heptachlor epoxide, dieldrin, BDE-47, p,p'-DDD. Although statistical modeling does not necessarily fully explain biological cause-effect relationships, relationships indicate that (1) the hypothalamic-pituitary-adrenal (HPA) axis in East Greenland polar bears is likely to be affected by OHC-contaminants and (2) the association between OHCs and cortisol may be linked with the hypothalamus-pituitary-thyroid (HPT) axis. (C) 2012 Elsevier Inc. All rights reserved.
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