Journal
ENVIRONMENTAL RESEARCH
Volume 109, Issue 3, Pages 292-300Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.envres.2008.11.010
Keywords
Cadmium; Urinary biomarkers; Estimated VO2 max; Cardiovascular fitness; Health disparities
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Objectives: We explored potential effects of cadmium exposure on cardiovascular fitness measures, including gender and racial/ethnic differences. Methods: Data were from the 1999 to 2000 National Health and Nutrition Examination Survey (NHANES); 1963 participating subjects were included in our analysis. Volume of oxygen consumed at sub-maximum activity (VO2 max) were recorded in a series of graded exercises; the goal was to elicit 75% of predetermined age-specific heart rates. Cadmium from urine samples was measured in the laboratory using standard methods. Multivariate linear regression analyses were performed to determine potential relationships. Results: Increased urinary cadmium concentrations were generally associated with decreased estimated VO2 max values. Gender and racial/ethnic differences were also observed. Specifically, associations were statistically significant for white males and Mexican American females. Conclusion: Inverse associations between urinary cadmium concentrations and estimated VO2 max values were observed, including racial and gender differences. The implications of such gender and racial/ethnic differences on long-term cardiovascular health and health disparities of present public health concern warrant further investigation. (C) 2008 Elsevier Inc. All rights reserved.
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