Journal
ENVIRONMENTAL POLLUTION
Volume 190, Issue -, Pages 133-138Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2014.03.026
Keywords
Generalized additive model; N, N-dimethylformamide; Relative risk; Gastrointestinal tract disease; Liver disease
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Funding
- National Natural Science Foundations of China [21307110]
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Occupational and experimental studies have revealed the organs most affected by dimethylformamide (DMF) are liver and gastrointestinal tract. However, few studies have focused on the potential effect of outdoor pollution of DMF. This study examined the health risk of hospitalization due to digestive system disease by time series studies in a case city Longwan, China. The urine metabolite of DMF was correlated well with DMF exposure concentration (EC). A 101.0-mu g/m(3) (interquartile range) increase in the two-day moving average of DMF EC was associated with a 1.10 (1.01(similar to)1.20), 1.22 (1.10(similar to)1.35), and 1.05 (0.90(similar to)1.22) increase in hospitalization for total digestive system diseases, liver disease, and gastrointestinal tract disease, respectively. The exposure-dose response between DMF and the relative risk of liver disease was linear only below 350 mu g/m(3). These findings highlight a previously unrecognized health problem related to VOCs released into the outdoor environment. (C) 2014 Elsevier Ltd. All rights reserved.
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