Journal
ENVIRONMENTAL POLLUTION
Volume 157, Issue 4, Pages 1317-1322Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2008.11.048
Keywords
Macrolides; Oxy-hydroxides; Adsorption/transformation; Environmental fate; Surface reaction
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The adsorption/transformation of two members (clarithromycin and roxithromycin) of the macrolide (ML) antibacterial agents on the surface of three environmental subsurface sorbents (clay, iron(III) and manganese(IV) oxy-hydroxides) was investigated. The adsorption fitted well to the Freundlich model with a high sorption capacity. Adsorption probably occurred through a surface complexation mechanism and was accompanied by slow degradation of the selected MLs. Transformation proceeded through two parallel pathways: a major pathway was the hydrolysis of the cladinose sugar, and to a lesser extent the hydrolysis of the lactone ring. A minor pathway was the N-dealkylation of the amino sugar. This study indicates that Fe(III) and Mn(IV) oxy-hydroxides in aquatic sediments may play an important role in the natural attenuation of MLs. Such an attenuation route yields a range of intermediates that might retain some of their biological activity. (C) 2008 Elsevier Ltd. All rights reserved.
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