Journal
ENVIRONMENTAL POLLUTION
Volume 157, Issue 4, Pages 1134-1139Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2008.08.013
Keywords
Fullerenes; Daphnia magna; In vitro; Nanotoxicity; Nanoparticles
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Funding
- European Commission [NMP4-CT-2004-500096]
- Federal Office for Professional Education and Technology - Innovation Promotion Agency (OPET - CTI)
- Swiss agency for the Environment (BAFU)
- Swiss Federal Office of Public Health (FOPH)
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Since the discovery of fullerenes in 1985, these carbon nanospheres have attracted attention regarding their physico/chemical properties. Despite little knowledge about their impact on the environment and human health, the production of fullerenes has already reached an industrial scale. However, the toxicity of C-60 is still controversially discussed. The aim of this study was to clarify the biological effects of tetrahydrofuran (THF) suspended C-60 fullerene in comparison to water stirred C-60 fullerene suspensions. Beyond that, we analyzed the effects on the Crustacea Daphnia magna an indicator for ecotoxicological effects and the human lung epithelial cell line A549 as a simplified model for the respiratory tract. We could demonstrate that water-soluble side products which were formed in THF nC(60) suspension were responsible for the observed acute toxic effects, whereas fullerenes themselves had no negative effect regardless of the preparative route on either A549 cell in vitro or D. magna in vivo. (C) 2008 Elsevier Ltd. All rights reserved.
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