Journal
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
Volume 305, Issue 1, Pages 169-178Publisher
SPRINGER
DOI: 10.1007/s10967-015-4026-4
Keywords
Iron oxide nanoparticles; Ga-68; Dual modality; Positron emission tomography; Magnetic resonance imaging
Funding
- Nuclear R&D Program through the Ministry of Science, ICT and Future Planning [2012M2A2A7035, 2010-0025899]
- Converging Research Center Program through the Ministry of Science, ICT and Future Planning [2013K000339]
- National Research Foundation of Korea (NRF) through the Ministry of Science, ICT and Future Planning [20142M2A2A6043061]
- National Research Foundation of Korea [2010-0025899] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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We designed a Ga-68 labeled Fe3O4 nano-biocomposite for dual applications as diagnostic imaging agent in positron emission tomography (PET)/magnetic resonance imaging (MRI). The nano-biocomposites ((GaNHFCNP)-Ga-68) were fabricated via surface modified iron oxide nanoparticles and NOTA as bi-functional chelating agent with Ga-68 isotopes from Ge-68/Ga-68 generator. The structure and morphological properties of nano-biocomposite was characterized by XRD, TEM and IR analysis. (68)GaNHFCNPs exhibits very low cytotoxicity and high cellular uptake upon SK-BR-3 and CT-26 cell lines. The advantages of high biocompatibility, magnetism and cell uptake make this composite promising as a potential probe of PET/MRI for effective detection of cancer.
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