Journal
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
Volume 308, Issue 2, Pages 733-739Publisher
SPRINGER
DOI: 10.1007/s10967-015-4479-5
Keywords
N-15; Triterpenic acid; Isotopic labelling; Pyrazine; Heterobetulinic acid
Funding
- Ministry of Education, Youth and Sports [LK21310]
- Technological Agency of the Czech Republic [TA03010027]
- CTU in Prague [SGS15/094/OHK4/1T/14]
- Czech Science Foundation [GJ15-08202Y, GA15-05620S]
- NPUII [LO1304, LO1204]
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Triterpenoid pyrazines from our research group were found selectively cytotoxic on several cancer cell lines with IC50 in low micromolar range. This sparked our interest in preparing their labeled analogs for metabolic studies. In this work, we prepared a set of non-labeled pyrazines from seven triterpenoid skeletal types along with their N-15 labelled analogs. In this work, we present the synthesis and characterization of the target N-15 labelled pyrazines. Currently, these compounds are being studied in complex metabolic studies.
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