Journal
ENVIRONMENTAL HEALTH PERSPECTIVES
Volume 117, Issue 9, Pages 1393-1396Publisher
US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
DOI: 10.1289/ehp.0900672
Keywords
pesticide exposure; preeclampsia; pregnancy-induced hypertension
Funding
- NATIONAL CANCER INSTITUTE [Z01CP010119, ZIACP010119] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [ZIAES049030, Z01ES049030, ZIAES045005, ZIAES049003] Funding Source: NIH RePORTER
- Intramural NIH HHS [Z01 ES049030, Z01 CP010119] Funding Source: Medline
- NCI NIH HHS [Z01 CP010119-12] Funding Source: Medline
- NIEHS NIH HHS [Z01 ES 049030-11] Funding Source: Medline
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BACKGROUND: Hypertensive disorders of pregnancy, including pregnancy- induced hypertension (PIH) and preeclampsia (PE), complicate 2-8% of pregnancies. Few studies have examined environmental risk factors in relation to these conditions. OBJECTIVES: Our goal was to examine whether pesticide exposure during pregnancy was associated with hypertensive disorders of pregnancy. METHODS: We analyzed self-reported data from 11,274 wives of farmers enrolled in the Agricultural Health Study (AHS) between 1993 and 1997. Using logistic regression models, we estimated the adjusted odds ratios (AORs) for PIH and PE associated with pesticide-related activities during the first trimester of pregnancy. RESULTS: First-trimester residential and agricultural activities with potential exposure to pesticides were associated with both PIH [residential AOR = 1.27; 95% confidence interval (CI), 1.02-1.60; agricultural AOR = 1.60; 95% Cl, 1.05-2.45] and PE (residential AOR = 1.32; 95% CI, 1.02-1.70; agricultural AOR = 2.07; 95% Cl, 1.34-3.21). CONCLUSIONS: Exposure to pesticides during pregnancy may increase the risk of hypertensive disorders of pregnancy. Laboratory research may provide insights into relationships between pesticide exposure and hypertensive diseases of pregnancy.
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