Journal
ENVIRONMENTAL ENTOMOLOGY
Volume 43, Issue 4, Pages 1117-1123Publisher
ENTOMOLOGICAL SOC AMER
DOI: 10.1603/EN13351
Keywords
insecticide resistance; Blattella germanica; pyrethroid; 2D-PAGE
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Funding
- Shandong Provincial Natural Science Foundation [ZR2012CQ040]
- Shandong Province Higher Educational Science and Technology Program [J11LC13]
- Shandong Province Medical and Health Science and Technology Development Program [2009HW055]
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A proteomic approach combining two-dimensional polyacrylamide gel electrophoresis and tandem mass spectrometry was used to compare hemolymph expression profiles of a beta-cypermethrin-resistant Blattella germanica L. strain and a beta-cypermethrin-susceptible strain. Twenty-eight hemolymph proteins were differentially expressed in the resistant cockroach strain; 19 proteins were upregulated and 9 proteins were downregulated compared with the susceptible strain. Protein identification indicated that expression of putative cuticular protein, nitric oxide synthase, triosephosphate isomerase, alpha-amylase, ABC transporter, and Per a 3 allergen was elevated, and expression of arginine kinase and glycosidase was reduced. The differential expression of these proteins reflects the overall change in cellular structure and metabolism related to the resistance of pyrethroid insecticides.
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