Journal
JOURNAL OF PSYCHIATRIC RESEARCH
Volume 71, Issue -, Pages 120-125Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychires.2015.09.017
Keywords
Gene set pathways; Gene-set enrichment analyses; Gene expression depression
Categories
Funding
- Academy of Finland [126925, 121584, 124282, 129378, 117787, 41071, 134309, 265977]
- Social Insurance Institution of Finland
- Kuopio University Hospital Medical Fund [9N035, X51001]
- Tampere University Hospital Medical Fund [9N035, X51001]
- Turku University Hospital Medical Fund [9N035, X51001]
- Juho Vainio Foundation
- Paavo Nurmi Foundation
- Finnish Foundation of Cardiovascular Research
- Finnish Cultural Foundation
- Tampere Tuberculosis Foundation
- Emil Aaltonen Foundation
- Yrjo Jahnsson Foundation
- Bothnia Welfare Coalition for Research and Knowledge network
- Signe and Ane Gyllenberg Foundation
- Laboratoriolaaketieteen edistamissaatio
- Finnish Medical Foundation
- ESRC [ES/J023299/1] Funding Source: UKRI
- MRC [MR/K013351/1] Funding Source: UKRI
- Economic and Social Research Council [ES/J023299/1] Funding Source: researchfish
- Medical Research Council [MR/K013351/1] Funding Source: researchfish
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We used genome wide expression (GWE) data of circulating blood cells and pathway analysis to investigate the inflammatory and other molecular pathways that may be associated with long-standing depressive symptoms. Participants were 607 women and 316 men (mean age 42 years) from the Young Finns Study who participated in three consecutive study phases in 2001, 2007 and 2012. Using Gene-set enrichment analyses (GSEA) we focused our analyses to pathways (available in MSigDB database) that are likely to affect immunological and inflammatory processes. GSEA were performed for blood cell GWE data in 2012. Depressive symptoms were assessed using a modified 21-item Beck Depression Inventory in each of the three study phases. Participants who scored in the top quartile of depressive symptoms in each of the three measurement points (n = 191) differed from other participants (n = 732) in several gene set pathways related to inflammatory processes or immune-inflammatory signaling including interleukin (IL-1) pathway, and pathways related to various immuno-inflammatory processes, such as toll-like, the NEF protein, the nuclear factor kB, the kinase ART and the mature B cell antigen receptor pathway (false discovery rates, FDRs <0.12). The results provide novel genome wide molecular evidence that support the association between chronic depressive symptoms and altered immune-inflammatory regulation. (c) 2015 Elsevier Ltd. All rights reserved.
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