Journal
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
Volume 49, Issue 1, Pages 9-15Publisher
WILEY-LISS
DOI: 10.1002/em.20342
Keywords
epigenetics; hepatocarcinogenesis; rodents; genotoxic carcinogens; non-genotoxic carcinogens
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Funding
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES012686] Funding Source: NIH RePORTER
- NIEHS NIH HHS [R01 ES012686, R01 ES012686-04] Funding Source: Medline
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Hepatocellular carcinoma which is one of the most prevalent life-threatening human cancers, is showing an increased incidence worldwide. Recent evidence indicates that the development of hepatocellular carcinoma is associated with not only genetic alterations, but also with profound epigenetic changes. This review summarizes the current knowledge about epigenetic alterations during rodent hepatocarcinogenesis, considers the similarities and differences in epigenetic effects of genotoxic and non-genotoxic rodent liver carcinogens, and discusses the possible role of these effects in the causality of liver tumor development.
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