Air pollution and hospitalization for epilepsy in Chile

Objective: To determine the association between gaseous and fine particulate air pollution (PM2.5) and epilepsy in a general population sample. Method: A daily time-series analyses tested the association between daily hospitalization for epilepsy in seven Chilean urban centers during the period 2001 and 2005. Results were adjusted for long term trends, day-of-the-week, and average humidex on the day of hospitalization and the day before. Results: Pooled city estimates of relative risk (95% CI) of hospitalization for epilepsy associated with changes in pollutant concentrations equivalent to their interquartile range were: 1.098(1.045, 1.155) for carbon monoxide (CO); 1.100 (1.025, 1.181) for ozone O-3; 1.085 (1.03, 1.144) for sulfur dioxide (SO2); 1.108 (1.021, 1.204) for nitrogen dioxide (NO2); 1.083(1.038, 1.13) for particulate matter <= 10 mu m diameter (PM10); and 1.065(1.002, 1.132) for fine particulate matter <= 2.5 mu m diameter (PM2.5). These results were not significantly influenced by age, sex, or season. Interpretation: Air pollution may be a risk factor for hospitalization for epilepsy. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.