Journal
ANNALS OF DERMATOLOGY
Volume 27, Issue 6, Pages 702-708Publisher
KOREAN DERMATOLOGICAL ASSOC
DOI: 10.5021/ad.2015.27.6.702
Keywords
Ankle brachial index; Alpha-2-HS-Glycoprotein; Behcet's disease; Cardiovascular diseases; Carotid intima-media thickness
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Background: Behcet's disease (BD) is a chronic, recurrent inflammatory systemic vasculitis. Evidence for increased atherosclerosis in BD has been observed. The relation between cardiovascular risk factors and increased atherosclerosis in patients with BD is still controversial. Objective: We performed this study to evaluate arterial stiffness in patients with BD by using noninvasive radiological methods such as carotid artery intima-media thickness (CIMT), ankle-brachial pressure index (ABPI), coronary artery calcium score (CACaS), and their relation to serum fetuin-A levels, which was recently found to be important in vascular calcification. Methods: This prospective study included 26 patients with BD and 25 control subjects. In all patients, the CIMT, ABPI, CACaS, and serum fetuin-A levels were examined. Results: The CIMT and CACaS were statistically higher and the ABPI was statistically lower in BD patients than in the control group. All p-values were <0.001. Positive correlations were found between the CACaS and CIMT, and negative correlations were found between the CACaS and ABPI. Although the values of fetuin-A were higher in BD, the difference was not statistically significant (p= 0.064). However, the correlations found between fetuin-A levels and CIMT and between fetuin-A levels and CACaS were significant. Conclusion: The CIMT, CACaS, and ABPI are all useful in detecting structural and functional vascular damage in BD.
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